What is aster spathulifolius?

As a perennial plant of the dicotyledonous plant campanulales asteraceae, because it is grown on the seaside, the aster spathulifolius is, also, called the “Daruma-giku”. After growing up obliquely, it grows up to the height of 30cm~60cm. Although the leaves are dislocated, with the shape as if an egg was erected upside down, because, at the bottom, it gathers, it is thick, and the hair has densely come out on both sides, it looks white, and, at the edges of the leaves, either they are flat or there are a little bit of the sawtooths. The flowers blossom from July until November. They are light purple. The fruits mature in November. And the pappai are light brown, and there are the gray furs. The leaves are edible. The aster spathulifolia are distributed at the south of the central part of Korea and in Japan. Ulleung-do, Gyeonggi-dong, and Jeju-do in our country are the main production places. Regarding the harvest, there is no special method. It grows in the wilderness. And the time for the harvest is around June ~ July and around October ~November.

The civilians have been using the young leaves for eating and the
turning hay for diabetes, bladder infection, etc. And, by utilizing the
tough life force that does not die in the winter and the special
characteristic of the lignification, they are made into the ornamental,
potted plants. Regarding the effect of improving the lipids in the
blood regarding the extract in the top part of the aster spathulifolius
and the anti-obesity effect, the research team at the Kyunghee
University had stated them.

Boesnbergia Pandurata

The standardization of the aster spathulifolius extract.

The index component of the aster spathulifolius extract is the germacrone. It has been standardized so that the content of the germacrone within the spathulifolius extract is 1% or higher.

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The safety of the aster spathulifolius extract.

  • The acute, oral toxicity test: The LD50 was 5,000 mg/kg b.w. or higher among the male and female mice.
  • The 13-week, repeated administration test: The NOAEL value was 2,000mg/kg/day among all of the males and females.
  • No mutagenicity or genotoxicity.

    - The chromosomal aberration test: The result was negative.

    - The mouse lymphoma test: Negative.

    - The Micronucleus Test: The result was negative.

  • The clinical test (Human Clinical Studies): No side-effect was reported.
  • The leaf has been registered as being edible in the Raw Food Materials Database of the Ministry of Food and Drug Safety.

The efficacy of the aster spathulifolius extract.

  • The effect of reducing the body fat: As a result of the human body application test, the significant reductions of the body weight, the body fat, the waist-to-hip ratio, the internal organs fat, and the subcutaneous fat had been confirmed.
  • The efficacy of improving the blood sugar: As a result of the animal tests, the effects of the significant improvements of the blood sugar resistance and the insulin resistance had been confirmed.

The theses related to the aster spathulifolius.

  • In vitro efficacy evaluation for preventing diabetes and diabetic complications from Aster spathulifolius
    (Food science and biotechnology, 2015, 24(1), 301-306).
  • Inhibitory effects of Aster spathulifolius extract on adipogenesis and lipid accumulation in 3T3-L1 preadipocytes
    (Journal of Pharmacy and Pharmacology; in press)
  • Anti-Diabetic Effect of Aster sphathulifolius in C57BL/KsJ-db/db Mice(Journal of Medicinal Food; in press)
  • Anti-obesity effects of Aster spathulifolius extract in high-fat diet-induced obese rats (Journal of Medicinal Food; in press)

Clinical Study : Weight Management

  • Testing substance: The aster spathulifolius extract. 700mg/day.
  • Test design: Randomized, double-blind, placebo-controlled. 12 weeks.
  • Subjects: n=40, the average weight (kg)- 77, the BMI (kg/㎡)- 25~30.
  • The method of the analysis: ITT(Intention-to-treat Analysis)/ANCOVA.

1. The body weight & body fat mass reduction.

  • As a result of comparing the weight and the BMI, by the time period of the ingestion, in the group that had ingested the aster spathulifolius extract, the weight and the amount of the body fat had been significantly reduced. (When having ingested 12 times, the weight had been reduced by 3.3kg (p=0.0004) and the body fat amount had been reduced by 2.38kg (p=0.0075).
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2. The reductions of the body fat (total fat, trunk fat, and leg fat), the internal organs fat, and the subcutaneous fat.

  • As a result of comparing the body fat (total fat, trunk fat, and leg fat), the internal organs fat, and the subcutaneous fat 12 weeks after the ingestion, in the group that had ingested the aster spathulifolius extract, the significant reductions of all of the body fat, the internal organs fat, and the subcutaneous fat had been confirmed.
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3. The mechanism of the efficacy of the weight adjustment of the aster spathulifolius extract.

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The animal study of the weight management.

1st study: The reduction of the abdominal fat and the weight.

  • As a result of testing with the obese mouse models that had been induced with the high-fat diet as the subjects, regarding the group that had ingested the high-fat diet + the aster spathulifolius extract for 12 weeks, compared to the high-fat diet group, the abdominal fat had been reduced, and the significant weight reductions had been confirmed
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2nd study: The reductions of the body fat and the internal organs fat.

  • As a result of testing with the obese mouse models that had been induced with a high-fat diet as the subjects, regarding the group that had ingested the high-fat diet and the aster spathulifolius extract for 12 weeks, compared to the high-fat diet group, the increase of the weight, the body fat, the abdominal fat, and the internal organs fat had been significantly reduced.
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2nd study: The reductions of the sizes of the fat cells.

  • Regarding the group that had ingested the high-fat diet and the aster spathulifolius extract for 12 weeks, compared to the high-fat diet group, the sizes of the fat cells had been significantly reduced.
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2nd study: The reductions of the TG and the TC and the increase of the HDL-C/TC.

  • Regarding the group that had ingested the high-fat diet and the aster spathulifolius extract for 12 weeks, compared to the high-fat diet group, it was confirmed that the triglyceride, the total cholesterol, and the HDL-C/TC had been significantly improved density-dependently.
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2nd study: The reductions of the leptin, the insulin, and the adiponectin.

  • It was confirmed that, regarding the group that had ingested the high-fat diet and the aster spathulifolius extract for 12 weeks, compared to the high-fat diet group, the leptin, the insulin, and the adiponectin had been significantly improved density-dependently.
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Animal study of blood glucose and insulin resistance

1. The reduction of the fasting blood sugar.

  • Weekly changes in the fasting blood glucose levels of C57BL/KsJ db/db mice that were administered Aster sphathulifolius extract.
  • In the group that had ingested 200mg/kg/day of the aster spathulifolius extract, from the 6th week of the ingestion, the effect of the significant reduction of the blood sugar was confirmed.
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2. Intraperitoneal glucose tolerance test (IPGTT)

  • It is thought that, by improving the insulin resistance of the type-2 diabetes, it had contributed to the adjustment of the blood sugar.
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As a material possessing the high water solubility, the aster spathulifolius extract can be applied to not only the beverages but, also, to the tablets, capsules, granules, etc.

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Specification

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This information has not been evaluated by the Food and Drug Administration.
This product is not for diagnosing, medically treating, or preventing the illnesses.