What is Licorice Extract, (HELICOLESS) ?

  • HELICOLESS is the Licorice Extract with the glycyrrhizin eliminated (deglycyrrhizinated Glycyrrhiza glabra extract). It was found that HELICOLESS effectively inhibits Helicobacter pylori growth and protect the stomach by in vitro, in vivo, and human clinical studies.
  • The raw material of HELICOLESS, licorice, has long been used worldwide
    as a traditional medicinal herb for its efficacy in the management of
    stomach ailments, cough, etc.
  • Licorice is GRAS(FDA, 1405-86-3) and listed in the Natural Health Products Ingredients database by Health Canada. And the Licorie Extract is listed in Australia TGA(Therapeutic Goods Administration) as the ingredient for Stomach Health(PI No. 107219,2010.9).
Boesnbergia Pandurata

Standardized HELICOLESS

Glabridin 28 mg/g - 44 mg/g

Safety of HELICOLESS

  • Oral Toxicity

    - Single dose oral toxicity: safe up to 5,000 mg/kg bw

    - 90 day repeated dose oral toxicity: NOAEL 1,000 mg/kg bw

  • Genotoxicity/Mutagenicity

    - Ames test (Salmonella typhimurium): negative

    - Chromosomal aberrations (In vitro, human lymphocytes): negative

    - Micronucleus test (In vivo, mouse bone marrow): negative

  • Human clinical studies: No adverse effects due to test substance observed
  • Glycyrrhiza glabra L.(Licorice) is listed as edible plant in Food Material Database of Korea Ministry of Food and Drug Safety.
  • HELICOLESS is approved as IAFF(Individually Approved health Functional Food) Ingredient by Korea Ministry of Food and Drug Safety (Certificate No.2014-4).

Efficacy of HELICOLESS

1. It helps stomach health by stomach protection

HELICOLESS shows the efficacy to protect the stomach from ulcer inducing factors. It is implicated that this efficacy may be due to its high antioxidant values (ORAC Value) and its anti-inflammatory action (it inhibits the generations of Prostaglandin, Thromboxane, and Leukotriene).

2. Efficacy of Anti-Helicobacter pylori

HELICOLESS exerts anti-H. pylori activity, which may result from its inhibitory activities on protein synthesis
(inhibiting methionine incorporation) and on DNA synthesis (inhibiting DNA gyrase and dihydrofolate reductase).

HELICOLESS의 Helicobacter pylori 억제 작용 기전

Anti-Helicobacter pylori Effect

HELICOLESS’ characteristics as DGL

HELICOLESS as deglycyrrhizinated Licorice Extract
( Glycyrrhizin content < 0.5% ) is highly differentiated from the conventional DGL by its excellent efficacy and high content of active compounds, further it can show efficacy in much smaller dose.

Item Conventional DGL HELICOLESS
Flavonoid content very low > 10%
Anti-oxidant very low very high
Anti-H. pylori very low Excellent
Effective Animal dose high-dose low-dose
Effective Human dose 1500~3000mg/day 150~300mg/day