In vivo studies
 

With being sporadically exposed to ultra violet light with concurrent HACP intake for 14 weeks, mouse showed distinguished effect of anti-aging of HACP.

 
 

In hairless mouse with 14 week intake of HACP in their feed with being sporadically exposed to ultra violet light showed

   
 
- distinguished reduction of wrinkles by visual assessment
 

- by instrument measurements

   
 

significant reduction of skin wrinkle and improvement of skin elasticity and skin hydration and significant improvement of skin erythema.

 

With being sporadically exposed to ultra violet light with concurrent HACP intake for 14 weeks, mouse showed the increase of hydroxyproline content at skin layer à indicating increase of collagen content at skin layer.

 

With being sporadically exposed to ultra violet light with concurrent HACP intake for 14 weeks, mouse showed decreased expression of protein, collagenase (MMP-3 & MMP-13) decomposing collagenà  inhibited decomposition of collagen at the skin layer.

 

With being sporadically exposed to ultra violet light with concurrent HACP intake for 14 weeks, mouse showed decreased expression of protein, gelatinase (MMP-2 & MMP-9) decomposing gelatinà  inhibited decomposition of gelatin at the skin layer.